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ITM2C Polyklonaler Antikörper

ITM2C Polyklonal Antikörper für IHC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

IHC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 13601-1-PBS

Synonyme

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  • Immunohistochemistry (IHC) staining of human colon tissue using ITM2C Polyclonal antibody (13601-1-AP)

    IHC staining of human colon using 13601-1-AP (same clone as 13601-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human colon tissue slide using 13601-1-AP (ITM2C antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 13601-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human colon tissue using ITM2C Polyclonal antibody (13601-1-AP)

    IHC staining of human colon using 13601-1-AP (same clone as 13601-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human colon tissue slide using 13601-1-AP (ITM2C antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 13601-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

13601-1-PBS bindet in IHC, Indirect ELISA ITM2C und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen ITM2C fusion protein Ag3876
Vollständiger Name integral membrane protein 2C
Berechnetes Molekulargewicht230aa,26 kDa; 267aa,30 kDa
Beobachtetes Molekulargewicht 30 kDa
GenBank-ZugangsnummerBC025742
Gene symbol ITM2C
Gene ID (NCBI) 81618
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

The Integral membrane protein 2C (ITM2C) is a type II integral transmembrane protein belonging to a family composed of at least two other members, ITM2A and ITM2B. ITM2C, often called transmembrane protein BRI3, is highly expressed in brain tissue. Yeast two-hybrid screen system revealed that BRI3 could interact with beta-secretase beta-amyloid protein converting enzyme (BACE)1 and the microtubule-destabilizing protein SCG10 (STMN2). It may play a role in TNF-induced cell death and neuronal differentiation. BRI3 was found to inhibit the various processing of amyloid precursor protein (APP) by blocking the access of alpha- and beta-secretases to APP, competitive inhibition of APP processing by BRI3 may provide a new approach to Alzheimer disease (AD) therapy and prevention.