IkB Alpha Polyklonaler Antikörper
IkB Alpha Polyklonal Antikörper für WB, IHC, IP, Indirect ELISA
Wirt / Isotyp
Kaninchen / IgG
Getestete Reaktivität
human, Maus
Anwendung
WB, IHC, IP, Indirect ELISA
Konjugation
Unkonjugiert
Kat-Nr. : 51066-1-PBS
Synonyme
Geprüfte Anwendungen
Produktinformation
51066-1-PBS bindet in WB, IHC, IP, Indirect ELISA IkB Alpha und zeigt Reaktivität mit human, Maus
Getestete Reaktivität | human, Maus |
Wirt / Isotyp | Kaninchen / IgG |
Klonalität | Polyklonal |
Typ | Antikörper |
Immunogen | Peptid |
Vollständiger Name | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
Berechnetes Molekulargewicht | 36 kDa |
Beobachtetes Molekulargewicht | 39 kDa |
GenBank-Zugangsnummer | BC002601 |
Gene symbol | IkB Alpha |
Gene ID (NCBI) | 4792 |
Konjugation | Unkonjugiert |
Form | Liquid |
Reinigungsmethode | Antigen-Affinitätsreinigung |
Lagerungspuffer | PBS only |
Lagerungsbedingungen | Store at -80°C. 20ul Größen enthalten 0,1% BSA. |
Hintergrundinformationen
Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (NFKBIA, synonyms: IKBA, MAD-3, NFKBI). NFKB1 or NFKB2 is bound to REL, RELA , or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime.