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IL-10 Rekombinanter Antikörper

IL-10 Rekombinant Antikörper für WB, Cytometric bead array, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

Maus

Anwendung

WB, Cytometric bead array, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

240430G12

Kat-Nr. : 82191-3-PBS

Synonyme

Il10, IL-10,IL10, 240430G12, CSIF, Il 10

Filter:
  • Western Blot (WB) analysis of various lysates using IL-10 Recombinant antibody (82191-3-RR)

    WB analysis using 82191-3-RR (same clone as 82191-3-PBS)

    Untreated, PMA, LPS and Brefeldin A treated RAW 264.7 cells were subjected to SDS PAGE followed by western blot with 82191-3-RR (Il10 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 82191-3-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

82191-3-PBS bindet in WB, Cytometric bead array, Indirect ELISA IL-10 und zeigt Reaktivität mit Maus

Getestete Reaktivität Maus
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen IL-10 fusion protein Eg0026
Vollständiger Name interleukin 10
Berechnetes Molekulargewicht 21 kDa
Beobachtetes Molekulargewicht20 kDa
GenBank-ZugangsnummerNM_010548
Gene symbol Il10
Gene ID (NCBI) 16153
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

IL-10 is an anti-inflammatory cytokine, produced by T helper (Th) cells, macrophages, monocytes, and B cells, that plays a crucial role in preventing inflammatory and autoimmune pathologies. It downregulates the expression of Th1 cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-κB activity, and is involved in the regulation of the JAK-STAT signaling pathway. IL-10, along with its receptors, describes an important role in pathogenesis of various diseases, including infectious, inflammatory, autoimmune diseases. IL-10 mutations are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.