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IL-19 Rekombinanter Antikörper

IL-19 Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

Maus

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

242880F12

Kat-Nr. : 85817-2-PBS

Synonyme

Il19, Interleukin-19

Filter:
  • Western Blot (WB) analysis of various lysates using IL-19 Recombinant antibody (85817-2-RR)

    WB analysis using 85817-2-RR (same clone as 85817-2-PBS)

    Human IL-19 Recombinant proteins were subjected to SDS PAGE followed by western blot with 85817-2-RR (Il19 antibody) at dilution of 1:1000 and incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85817-2-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

85817-2-PBS bindet in WB, Indirect ELISA IL-19 und zeigt Reaktivität mit Maus

Getestete Reaktivität Maus
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen IL-19 fusion protein Eg2844
Vollständiger Name interleukin 19
Berechnetes Molekulargewicht20 kDa
GenBank-ZugangsnummerNM_001009940.1
Gene symbol Il19
Gene ID (NCBI) 329244
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

IL-19, a member of the IL-10 cytokine family (IL-10, -19, -20, -22, -24, -26, -28, and -29), is expressed in epithelial cells, endothelial cells, and macrophages. It can bind the interleukin-20 receptor complex IL-20R1/IL-20R2 and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). IL-19 induces IL-6 and TNF-α production in monocytes. It also induces cell apoptosis and reactive oxygen species production in monocytes, which suggests a role of this cytokine in inflammatory responses. It is up-regulated in monocytes following stimulation with lipopolysaccharide (LPS), and granulocyte-macrophage colony-stimulating factor (GM-CSF). IL-19 alters the balance of Th1 and Th2 cells in favor of Th2 cells. IL-19 contributes to a range of diseases and disorders, such as breast cancer, squamous cell carcinoma of the skin, asthma, endotoxic shock, uremia, psoriasis, rheumatoid arthritis, and periodontal and vascular disease.