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Integrin alpha 6 Monoklonaler Antikörper

Integrin alpha 6 Monoklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Maus / IgG2b

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

2B12A1

Kat-Nr. : 66906-1-PBS

Synonyme

ITGA6, 2B12A1, CD49 antigen-like family member F, CD49f, Integrin alpha-6

Filter:
  • Western Blot (WB) analysis of A431 cells using Integrin alpha 6 Monoclonal antibody (66906-1-Ig)

    WB analysis of A431 using 66906-1-Ig (same clone as 66906-1-PBS)

    A431 cells were subjected to SDS PAGE followed by western blot with 66906-1-Ig (Integrin alpha-6 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66906-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of JAR cells using Integrin alpha 6 Monoclonal antibody (66906-1-Ig)

    WB analysis of JAR using 66906-1-Ig (same clone as 66906-1-PBS)

    JAR cells were subjected to SDS PAGE followed by western blot with 66906-1-Ig (Integrin Alpha 6 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66906-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of human placenta tissue using Integrin alpha 6 Monoclonal antibody (66906-1-Ig)

    WB analysis of human placenta using 66906-1-Ig (same clone as 66906-1-PBS)

    human placenta tissue were subjected to SDS PAGE followed by western blot with 66906-1-Ig (Integrin Alpha 6 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66906-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

66906-1-PBS bindet in WB, Indirect ELISA Integrin alpha 6 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Maus / IgG2b
Klonalität Monoklonal
Typ Antikörper
Immunogen Integrin alpha 6 fusion protein Ag25866
Vollständiger Name integrin, alpha 6
Berechnetes Molekulargewicht 1073 aa, 119 kDa
Beobachtetes Molekulargewicht 115-120 kDa
GenBank-ZugangsnummerBC136456
Gene symbol Integrin alpha 6
Gene ID (NCBI) 3655
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands, cell-surface ligands, and soluble ligands (PMID: 17543136). They are transmembrane αβ heterodimers and at least 24 distinct integrin heterodimers are formed by the combination of 18 α and eight β known subunits (PMID: 17543136; 20029421). In addition to mediating cell adhesion, integrins also play important roles in modulating signal transduction pathways that control cellular responses including migration, proliferation, differentiation, and apoptosis (PMID:19118207). Integrin alpha 6 (ITGA6, also known as CD49f or VLA-6) is a 120-kDa single-pass type 1 transmembrane glycoprotein, which combines with the beta 1 subunit (ITGB1, CD29) or beta 4 subunit (ITGB4, CD104) to form heterodimeric laminin receptors (PMID: 1976638; 2351695). Integrin alpha 6 mediates cell-to-cell and cell-to-stroma adhesion. It has also been found in many different stem cell populations and is involved in homing and connecting stem cells to their niches and regulating self-renewal mechanisms in stem cells (PMID: 28494695).