Integrin alpha 11 Rekombinanter Antikörper

Integrin alpha 11 Rekombinant Antikörper für WB, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus

Anwendung

WB, ELISA

Konjugation

Unkonjugiert

CloneNo.

241351B7

Kat-Nr. : 84695-1-RR

Synonyme

ITGA11, Integrin alpha-11, 241351B7

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  WB analysis using 84695-1-RR

  Various lysates were subjected to SDS PAGE followed by western blot with 84695-1-RR (Integrin alpha 11 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in WB: SH-SY5Y-Zellen, A549-Zellen, HeLa-Zellen, Neuro-2a-Zellen

Empfohlene Verdünnung

• Western Blot (WB): WB : 1:500-1:2000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Produktinformation

84695-1-RR bindet in WB, ELISA Integrin alpha 11 und zeigt Reaktivität mit human, Maus

• Getestete Reaktivität: human, Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: Peptid
• Vollständiger Name: integrin, alpha 11
• Berechnetes Molekulargewicht: 133 kDa
• Beobachtetes Molekulargewicht: 170 kDa
• GenBank-Zugangsnummer: NM_001004439
• Gene symbol: ITGA11
• Gene ID (NCBI): 22801
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein A purfication
• Lagerungspuffer: PBS with 0.02% sodium azide and 50% glycerol
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands, cell-surface ligands, and soluble ligands (PMID: 17543136). They are transmembrane αβ heterodimers and at least 24 distinct integrin heterodimers are formed by the combination of 18 α and eight β known subunits (PMID: 17543136; 20029421). In addition to mediating cell adhesion, integrins also play important roles in modulating signal transduction pathways that control cellular responses including migration, proliferation, differentiation, and apoptosis (PMID:19118207). Integrin alpha 11 (ITGA11) combines with the beta 1 subunit (ITGB1, CD29) to form a cell-surface receptor for collagen. This receptor is involved in cell migration and collagen reorganization on mesenchymal nonmuscle cells (PMID: 11518510). It is also involved in the regulation of myofibroblast phenotypic differentiation during fibrotic diseases (PMID: 29147013).