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Integrin alpha 2 Polyklonaler Antikörper

Integrin alpha 2 Polyklonal Antikörper für WB, IF/ICC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, IF/ICC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 30703-1-PBS

Synonyme

ITGA2, BR, CD49B, Collagen receptor, GPIa

Filter:
  • Western Blot (WB) analysis of various lysates using Integrin alpha 2 Polyclonal antibody (30703-1-AP)

    WB analysis using 30703-1-AP (same clone as 30703-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 30703-1-AP (Integrin alpha 2 antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 30703-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of various lysates using Integrin alpha 2 Polyclonal antibody (30703-1-AP)

    WB analysis using 30703-1-AP (same clone as 30703-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 30703-1-AP (Integrin alpha-2 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 30703-1-PBS in a different storage buffer formulation.

  • Immunofluorescence (IF) / fluorescent staining of A431 cells using Integrin alpha 2 Polyclonal antibody (30703-1-AP)

    IF Staining of A431 using 30703-1-AP (same clone as 30703-1-PBS)

    Immunofluorescent analysis of (-20°C Methanol) fixed A431 cells using ITGA2 antibody (30703-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 30703-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

30703-1-PBS bindet in WB, IF/ICC, Indirect ELISA Integrin alpha 2 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen Integrin alpha 2 fusion protein Ag32771
Vollständiger Name integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
Berechnetes Molekulargewicht126 kDa
Beobachtetes Molekulargewicht140-150 kDa
GenBank-ZugangsnummerNM_002203
Gene symbol Integrin alpha 2
Gene ID (NCBI) 3673
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands, cell-surface ligands, and soluble ligands (PMID: 17543136). They are transmembrane αβ heterodimers and at least 24 distinct integrin heterodimers are formed by the combination of 18 α and eight β known subunits (PMID: 17543136; 20029421). In addition to mediating cell adhesion, integrins also play important roles in modulating signal transduction pathways that control cellular responses including migration, proliferation, differentiation, and apoptosis (PMID:19118207). Integrin alpha-2 (ITGA2, CD49b) combines with the beta 1 subunit (ITGB1, CD29) to form a cell-surface receptor (VLA-2) for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin.