Integrin alpha-5/CD49e Monoklonaler Antikörper

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• KD/KO Validated

Integrin alpha-5/CD49e Monoklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Maus / IgG2a

Getestete Reaktivität

Hausschwein, human, Kaninchen, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

3B9E5

Kat-Nr. : 68561-1-PBS

Synonyme

Integrin Alpha-5, ITGA5, 3B9E5, CD49 antigen-like family member E, CD49e

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  WB analysis using 68561-1-Ig (same clone as 68561-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 68561-1-Ig (Integrin alpha-5 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68561-1-PBS in a different storage buffer formulation.

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  WB analysis of HAP1 using 68561-1-Ig (same clone as 68561-1-PBS)

  WB result of Integrin alpha-5/CD49e antibody (68561-1-Ig; 1:8000; room temperature for 1.5 hours) with wild-type and Integrin alpha-5/CD49e knockout HAP1 cells. This data was developed using the same antibody clone with 68561-1-PBS in a different storage buffer formulation.

• 

  WB analysis using 68561-1-Ig (same clone as 68561-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 68561-1-Ig (Integrin alpha-5 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68561-1-PBS in a different storage buffer formulation.

• 

  WB analysis of Jurkat using 68561-1-Ig (same clone as 68561-1-PBS)

  Jurkat cells were subjected to SDS PAGE followed by western blot with 68561-1-Ig (Integrin alpha-5 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68561-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

68561-1-PBS bindet in WB, Indirect ELISA Integrin alpha-5/CD49e und zeigt Reaktivität mit Hausschwein, human, Kaninchen, Maus, Ratten

• Getestete Reaktivität: Hausschwein, human, Kaninchen, Maus, Ratte
• Wirt / Isotyp: Maus / IgG2a
• Klonalität: Monoklonal
• Typ: Antikörper
• Immunogen: Integrin alpha-5/CD49e fusion protein Ag33642
• Vollständiger Name: integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
• Berechnetes Molekulargewicht: 115 kDa
• Beobachtetes Molekulargewicht: 140 kDa
• GenBank-Zugangsnummer: BC008786
• Gene symbol: Integrin alpha 5
• Gene ID (NCBI): 3678
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Integrins are cell adhesion receptors that are heterodimers composed of non-covalently associated alpha and beta subunits. Integrin alpha 5 (ITGA5), belongs to the integrin alpha chain family, primarily binds to Integrin beta 1 (ITGB1) to form an α5β1 heterodimer (PMID: 33711961). Integrin α5β1 is a specific receptor of fibronectin through its arginine-glycine-aspartic acid (RGD) binding site (PMID: 19608542). Integrin α5β1 plays roles in cell adhesion, migration and matrix formation, and has emerged as an essential mediator in many human carcinomas (PMID: 33408483).