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Integrin alpha 6 Rekombinanter Antikörper

Integrin alpha 6 Rekombinant Antikörper für IF/ICC, Cytometric bead array, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

IF/ICC, Cytometric bead array, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

241703E3

Kat-Nr. : 84463-2-PBS

Synonyme

ITGA6, 241703E3, CD49 antigen-like family member F, CD49f, Integrin alpha-6

Filter:
  • Immunofluorescence (IF) / fluorescent staining of A431 cells using Integrin alpha 6 Recombinant antibody (84463-2-RR)

    IF Staining of A431 using 84463-2-RR (same clone as 84463-2-PBS)

    Immunofluorescent analysis of (4% PFA) fixed A431 cells using Integrin alpha 6 antibody (84463-2-RR, Clone: 241703E3 ) at dilution of 1:1000 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 84463-2-PBS in a different storage buffer formulation.

  • Cytometric bead array standard curve of MP01334-1

    Cytometric bead array standard curve of MP01334-1

    Cytometric bead array standard curve of MP01334-1, Integrin alpha-6 Recombinant Matched Antibody Pair, PBS Only. Capture antibody: 84463-1-PBS. Detection antibody: 84463-2-PBS. Standard: RP00013. Range: 0.781-100 ng/mL.

  • Affinity and Kinetic Characterization of 84463-2-RR

    Affinity and Kinetic Characterization of 84463-2-RR

    Biolayer interferometry (BLl) kinetic assays of 84463-2-RR against Human Integrin alpha 6 were performed. The affinity constant is 13.3 nM.

Geprüfte Anwendungen

Produktinformation

84463-2-PBS bindet in IF/ICC, Cytometric bead array, Indirect ELISA Integrin alpha 6 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Rekombinantes Protein
Vollständiger Name integrin, alpha 6
Berechnetes Molekulargewicht 1073 aa, 119 kDa
GenBank-ZugangsnummerBC136456
Gene symbol Integrin alpha 6
Gene ID (NCBI) 3655
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands, cell-surface ligands, and soluble ligands (PMID: 17543136). They are transmembrane αβ heterodimers and at least 24 distinct integrin heterodimers are formed by the combination of 18 α and eight β known subunits (PMID: 17543136; 20029421). In addition to mediating cell adhesion, integrins also play important roles in modulating signal transduction pathways that control cellular responses including migration, proliferation, differentiation, and apoptosis (PMID:19118207). Integrin alpha 6 (ITGA6, also known as CD49f or VLA-6) is a 120-kDa single-pass type 1 transmembrane glycoprotein, which combines with the beta 1 subunit (ITGB1, CD29) or beta 4 subunit (ITGB4, CD104) to form heterodimeric laminin receptors (PMID: 1976638; 2351695). Integrin alpha 6 mediates cell-to-cell and cell-to-stroma adhesion. It has also been found in many different stem cell populations and is involved in homing and connecting stem cells to their niches and regulating self-renewal mechanisms in stem cells (PMID: 28494695).