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Integrin alpha-9 Polyklonaler Antikörper

Integrin alpha-9 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 28348-1-PBS

Synonyme

Filter:
  • Western Blot (WB) analysis of various lysates using Integrin alpha-9 Polyclonal antibody (28348-1-AP)

    WB analysis using 28348-1-AP (same clone as 28348-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 28348-1-AP (Integrin alpha 9 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 28348-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

28348-1-PBS bindet in WB, Indirect ELISA Integrin alpha-9 und zeigt Reaktivität mit human, Maus

Getestete Reaktivität human, Maus
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen Integrin alpha-9 fusion protein Ag28815
Vollständiger Name integrin, alpha 9
Berechnetes Molekulargewicht 114 kDa
Beobachtetes Molekulargewicht135 kDa
GenBank-ZugangsnummerBC030198
Gene symbol Integrin alpha 9
Gene ID (NCBI) 3680
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Integrins are cell adhesion receptors that are heterodimers composed of non-covalently associated α and β subunits (PMID: 9779984). Integrin alpha 9 contains a large N-terminal extracellular domain with 7 conserved repeats of putative metal-binding domains, a transmembrane segment, and a short C-terminal cytoplasmic tail (PMID: 8245132). Integrin alpha 9 interacts with integrin beta 1 generating α9β1 heterodimer, which is expressed in many cell types including epithelial cells, neutrophils, hepatocytes, muscle and endothelial cells (PMID: 21975548). It binds to a diversity of ligands in the extracellular matrix, like the a-disintegrin and metalloprotease (ADAM) family, THBS1, EMILIN1, VEGF, tenascin-C, osteopontin, fibronectin, and VCAM1 (PMID: 21975548; 33790909). Integrin α9β1 has been implicated in diverse biological functions including angiogenesis, lymphangiogenesis, lymphatic valve morphogenesis, granulopoiesis and tumorigenesis (PMID: 20179422).