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Integrin beta 3 Rekombinanter Antikörper

Integrin beta 3 Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

230292A10

Kat-Nr. : 83053-6-PBS

Synonyme

CD61, GP3A, GPIIIa, Integrin beta 3, ITGB3

Filter:
  • Western Blot (WB) analysis of human peripheral blood platelets using Integrin beta 3 Recombinant antibody (83053-6-RR)

    WB analysis of human peripheral blood platelets using 83053-6-RR (same clone as 83053-6-PBS)

    human peripheral blood platelets were subjected to SDS PAGE followed by western blot with 83053-6-RR (Integrin beta-3 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 83053-6-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

83053-6-PBS bindet in WB, Indirect ELISA Integrin beta 3 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Peptid
Vollständiger Name integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
Berechnetes Molekulargewicht 87 kDa
Beobachtetes Molekulargewicht100-110 kDa
GenBank-ZugangsnummerBC127667
Gene symbol Integrin beta 3
Gene ID (NCBI) 3690
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Integrin beta-3, also named as CD61 and GPIIIa, is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin beta-3 recognize the sequence R-G-D in a wide array of ligands and the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen which leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. Human integrin beta-3 has a calculated molecular weight of 87 kDa. As a result of glycosylation, the apparent molecular mass of integrin beta-3 is approximately 90-110 kDa.