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Integrin beta-8 Rekombinanter Antikörper

Integrin beta-8 Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

241549A12

Kat-Nr. : 84558-1-PBS

Synonyme

ITGB8, integrin, beta 8, Integrin beta 8, 241549A12

Filter:
  • Western Blot (WB) analysis of various lysates using Integrin beta-8 Recombinant antibody (84558-1-RR)

    WB analysis using 84558-1-RR (same clone as 84558-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84558-1-RR (Integrin beta-8 antibody) at dilution of 1:4500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84558-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84558-1-RR

    Affinity and Kinetic Characterization of 84558-1-RR

    Biolayer interferometry (BLl) kinetic assays of 84558-1-RR against Human Integrin beta-8 were performed. The affinity constant is below 1 pM.

Geprüfte Anwendungen

Produktinformation

84558-1-PBS bindet in WB, Indirect ELISA Integrin beta-8 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Integrin beta-8 fusion protein Ag31161
Vollständiger Name integrin, beta 8
Berechnetes Molekulargewicht 86 kDa
Beobachtetes Molekulargewicht95-100 kDa
GenBank-ZugangsnummerNM_002214
Gene symbol Integrin beta 8
Gene ID (NCBI) 3696
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Integrins are cell adhesion receptors that are heterodimers composed of non-covalently associated alpha and beta subunits. Integrin beta-8 (ITGB8), belongs to the integrin beta chain family, contains an N-terminal signal peptide, a large extracellular domain that includes four cysteine-rich repeats, a transmembrane domain, and a C-terminal cytoplasmic domain (PMID: 1918072). Integrin beta-8 associates with integrin alpha-V (ITGAV) to form an αvβ8 heterodimer which has been shown to bind vitronectin, fibronectin, and a latency-associated peptide of TGF-β1/3 (PMID: 27033701). Integrin beta-8 contains multiple potential N-linked glycosylation sites. The observed molecular mass of approximately 95-100 kDa for integrin beta-8 is larger than the predicted 86 kDa, consistent with substantial glycosylation (PMID: 1918072).