KANSL3 Polyklonaler Antikörper

KANSL3 Polyklonal Antikörper für WB, IHC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, IHC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 25533-1-PBS

Synonyme

KIAA1310, KAT8 regulatory NSL complex subunit 3, PRTD, NSL3, NSL complex protein NSL3

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  WB analysis using 25533-1-AP (same clone as 25533-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 25533-1-AP (KANSL3 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 25533-1-PBS in a different storage buffer formulation.

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  IHC staining of human intrahepatic cholangiocarcinoma using 25533-1-AP (same clone as 25533-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human intrahepatic cholangiocarcinoma tissue slide using 25533-1-AP (KANSL3 antibody) at dilution of 1:200 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 25533-1-PBS in a different storage buffer formulation.

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  IHC staining of human intrahepatic cholangiocarcinoma using 25533-1-AP (same clone as 25533-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human intrahepatic cholangiocarcinoma tissue slide using 25533-1-AP (KANSL3 antibody) at dilution of 1:200 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 25533-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

25533-1-PBS bindet in WB, IHC, Indirect ELISA KANSL3 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: KANSL3 fusion protein Ag22117
• Vollständiger Name: KIAA1310
• Berechnetes Molekulargewicht: 878 aa, 93 kDa
• Beobachtetes Molekulargewicht: 105 kDa
• GenBank-Zugangsnummer: BC063792
• Gene symbol: KANSL3
• Gene ID (NCBI): 55683
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

KANSL3, or KAT8-associated nonspecific lethal complex subunit 3, is a component of the KANSL complex, which is an important chromatin modifier in higher animals. This complex plays a crucial role in regulating housekeeping genes and is highly conserved across species. KANSL3, along with other KANSL complex members, is essential for cell division and has been shown to interact robustly both in vitro and in vivo. KANSL3 has been found to have a dual role in cellular function. In interphase, KANSL3 is chromatin-bound and regulates the expression of housekeeping genes. During mitosis, KANSL3 relocates to the mitotic spindle and is important for cell division. It has been identified as a microtubule minus-end-binding protein, which is a novel function for a chromatin-binding complex. KANSL3's ability to bind directly to microtubule minus ends is significant, as very few proteins are known to perform this function.