KATNAL1 Rekombinanter Antikörper

KATNAL1 Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

242796B5

Kat-Nr. : 85382-1-PBS

Synonyme

p60 katanin like 1, Katanin p60 subunit A-like 1, katanin p60 subunit A like 1, Katanin p60 ATPase-containing subunit A-like 1, EC:5.6.1.1

---

• 

  WB analysis using 85382-1-RR (same clone as 85382-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 85382-1-RR (KATNAL1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85382-1-PBS in a different storage buffer formulation.

• 

  WB analysis using 85382-1-RR (same clone as 85382-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 85382-1-RR (KATNAL1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85382-1-PBS in a different storage buffer formulation.

---

Geprüfte Anwendungen

Produktinformation

85382-1-PBS bindet in WB, Indirect ELISA KATNAL1 und zeigt Reaktivität mit human, Ratten

• Getestete Reaktivität: human, Ratte
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: KATNAL1 fusion protein Ag13960
• Vollständiger Name: katanin p60 subunit A-like 1
• Berechnetes Molekulargewicht: 490 aa, 55 kDa
• Beobachtetes Molekulargewicht: 50-55 kDa
• GenBank-Zugangsnummer: BC000612
• Gene symbol: KATNAL1
• Gene ID (NCBI): 84056
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

KATNAL1 belongs to a family of microtubule-severing proteins and contains an N-terminal microtubule interaction and trafficking (MIT) domain, an ATPase AAA-type core domain, and a C-terminal Vps4_C domain. KATNAL1 is involved in regulating microtubule dynamics, which is essential for spermiogenesis and male fertility. It severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays(PMID: 22654668). In neurons, KATNAL1 plays a role in microtubule rearrangement during neuronal migration and process elongation. Additionally, mutations in KATNAL1 have been associated with intellectual disability and microcephaly in humans(PMID: 30448058).