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KCC2/SLC12A5-Specific Rekombinanter Antikörper

KCC2/SLC12A5-Specific Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

Hausschwein, human, Maus

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

243141H8

Kat-Nr. : 85751-1-PBS

Synonyme

KCC2, KCC2/SLC12A5, SLC12A5, Electroneutral potassium-chloride cotransporter 2, hKCC2

Filter:
  • Western Blot (WB) analysis of various lysates using KCC2/SLC12A5-Specific Recombinant antibody (85751-1-RR)

    WB analysis using 85751-1-RR (same clone as 85751-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 85751-1-RR (KCC2/SLC12A5-Specific antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85751-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

85751-1-PBS bindet in WB, Indirect ELISA KCC2/SLC12A5-Specific und zeigt Reaktivität mit Hausschwein, human, Maus

Getestete Reaktivität Hausschwein, human, Maus
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Peptid
Vollständiger Name solute carrier family 12 (potassium-chloride transporter), member 5
Berechnetes Molekulargewicht 126 kDa
Beobachtetes Molekulargewicht 130-150 kDa
GenBank-ZugangsnummerNM_020708
Gene symbol KCC2
Gene ID (NCBI) 57468
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

KCC2, encoded by SLC12A5, is a neuron-specific K+-Cl- cotransporter that is essential for Cl- homeostasis and inhibitory synaptic transmission in brain. KCC2 is expressed at high levels in neurons throughout the nervous system. KCC2 deletion caused animal death. Alterations of KCC2 have been linked to neuropathic pain, temporal lobe epilepsy, and other diseases. This antibody can detect 130-150 kDa monomer and ~250 kDa dimer of KKC2 in brain lysate. (PMID: 23401525)