KCNIP3 Rekombinanter Antikörper

KCNIP3 Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

251515A1

Kat-Nr. : 86579-1-PBS

Synonyme

A-type potassium channel modulatory protein 3, Calsenilin, DRE-antagonist modulator, Kv channel-interacting protein 3

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  WB analysis using 86579-1-RR (same clone as 86579-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 86579-1-RR (KCNIP3 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86579-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 86579-1-RR

  Biolayer interferometry (BLl) kinetic assays of 86579-1-RR against Human KCNIP3 were performed. The affinity constant is 0.903 nM.

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Geprüfte Anwendungen

Produktinformation

86579-1-PBS bindet in WB, Indirect ELISA KCNIP3 und zeigt Reaktivität mit human, Maus, Ratten

• Getestete Reaktivität: human, Maus, Ratte
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: KCNIP3 fusion protein Ag2665
• Vollständiger Name: Kv channel interacting protein 3, calsenilin
• Berechnetes Molekulargewicht: 256 aa, 29 kDa
• Beobachtetes Molekulargewicht: 29 kDa
• GenBank-Zugangsnummer: BC012850
• Gene symbol: KCNIP3
• Gene ID (NCBI): 30818
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

KCNIP3 also known as Calsenilin, CSEN, DREAM, or KCHIP3, is a protein-coding gene located on human chromosome 2q11.1 . It encodes a small calcium-binding protein belonging to the recoverin branch of the EF-hand superfamily. KCNIP3 is an integral subunit of native Kv4 channel complexes, regulating A-type potassium currents in response to intracellular calcium changes, thereby modulating neuronal excitability. KCNIP3 interacts with presenilin 1 (PSEN1) and presenilin 2 (PSEN2), influencing γ-secretase activity and β-amyloid formation, potentially linking it to Alzheimer's disease pathology.