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KCTD7 Polyklonaler Antikörper

KCTD7 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 32488-1-PBS

Synonyme

BTB/POZ domain-containing protein KCTD7

Filter:
  • Western Blot (WB) analysis of various lysates using KCTD7 Polyclonal antibody (32488-1-AP)

    WB analysis using 32488-1-AP (same clone as 32488-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 32488-1-AP (KCTD7 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 32488-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

32488-1-PBS bindet in WB, Indirect ELISA KCTD7 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen KCTD7 fusion protein Ag35756
Vollständiger Name potassium channel tetramerisation domain containing 7
Berechnetes Molekulargewicht33 kDa，289 aa
Beobachtetes Molekulargewicht62 kDa
GenBank-ZugangsnummerNM_153033.4
Gene symbol KCTD7
Gene ID (NCBI) 154881
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

KCTD7, or Potassium Channel Tetramerization Domain Containing 7, is a member of the KCTD family of proteins. The role of KCTD7 in regulating autophagy-lysosome pathways, which are essential for cellular homeostasis and response to nutrient stress (PMID: 36964131). It has been implicated in several neurodegenerative disorders, particularly progressive myoclonic epilepsy (PME) and neuronal ceroid lipofuscinosis (NCL). The deficiency of KCTD7 results in the accumulation of lipofuscin and lipid droplets, which are hallmarks of NCL (PMID: 33970744). The 62 kDa form most likely corresponds to an SDS-stable dimer (PMID: 22748208).