VEGF Receptor 2 Polyklonaler Antikörper

VEGF Receptor 2 Polyklonal Antikörper für ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human und mehr (1)

Anwendung

IHC,ELISA

Konjugation

Unkonjugiert

Publikationen

1

Kat-Nr. : 18975-1-AP

Synonyme

CD309, Fetal liver kinase 1, FLK 1, FLK1, KDR, Kinase insert domain receptor, VEGF Receptor 2, VEGFR, VEGFR 2, VEGFR2

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Galerie der Validierungsdaten

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  IHC staining of human breast cancer using 18975-1-AP

  Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 18975-1-AP (VEGF Receptor 2 antibody at dilution of 1:50 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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  IHC staining of human breast cancer using 18975-1-AP

  Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 18975-1-AP (VEGF Receptor 2 antibody at dilution of 1:50 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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  IHC staining of human colon cancer using 18975-1-AP

  Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 18975-1-AP (VEGF Receptor 2 antibody at dilution of 1:50 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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  IHC staining of human colon cancer using 18975-1-AP

  Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 18975-1-AP (VEGF Receptor 2 antibody at dilution of 1:50 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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  IHC staining of human placenta using 18975-1-AP

  Immunohistochemical analysis of paraffin-embedded human placenta using 18975-1-AP (VEGF Receptor 2 antibody) at dilution of 1:50 (under 10x lens).

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  IHC staining of human placenta using 18975-1-AP

  Immunohistochemical analysis of paraffin-embedded human placenta using 18975-1-AP (VEGF Receptor 2 antibody) at dilution of 1:50 (under 40x lens).

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Geprüfte Anwendungen

Empfohlene Verdünnung

Anwendung	Verdünnung
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Veröffentlichte Anwendungen

• IHC: See 1 publications below

Produktinformation

18975-1-AP bindet in IHC,ELISA VEGF Receptor 2 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• In Publikationen genannte Reaktivität: Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: Peptid
• Vollständiger Name: kinase insert domain receptor (a type III receptor tyrosine kinase)
• Berechnetes Molekulargewicht: 152 kDa
• GenBank-Zugangsnummer: NM_002253
• Gene symbol: KDR
• Gene ID (NCBI): 3791
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS mit 0.02% Natriumazid und 50% Glycerin pH 7.3.
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

KDR, also named as VEGFR-2, FLK1 and CD309, is a receptor for VEGF or VEGFC. KDR which belongs to the protein kinase superfamily, has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. KDR functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. Mutations of this gene are implicated in infantile capillary hemangiomas.

Publikationen

Species	Application	Title
mouse	IHC	Kidney Int; TNF-mediated damage to glomerular endothelium is an important determinant of acute kidney injury in sepsis.; Authors - Xu Chang C