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KEAP1 Polyklonaler Antikörper

KEAP1 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 30041-1-PBS

Synonyme

Filter:
  • Western Blot (WB) analysis of various lysates using KEAP1 Polyclonal antibody (30041-1-AP)

    WB analysis using 30041-1-AP (same clone as 30041-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 30041-1-AP (KEAP1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 30041-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

30041-1-PBS bindet in WB, Indirect ELISA KEAP1 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen KEAP1 fusion protein Ag32512
Vollständiger Name kelch-like ECH-associated protein 1
Berechnetes Molekulargewicht 624 aa, 70 kDa
Beobachtetes Molekulargewicht55-70 kDa
GenBank-ZugangsnummerBC002930
Gene symbol KEAP1
Gene ID (NCBI) 9817
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

KEAP1, also named as INRF2, KIAA0132 and KLHL19, is part of a multiprotein complex that contains the CUL3-ROC1 ubiquitin ligase, which can ubiquitinate the N-terminal domain of NRF2[PMID: 20173742]. Two molecules of KEAP1 bind to two distinct sites in the N-terminal region of NRF2, the ETGE and DLG sites, which affect the KEAP1-NRF2 interaction and/or its physiological consequences[PMID: 22215675]. KEAP1 retains NFE2L2/NRF2 in the cytosol. It functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1[PMID: 20427290]. It also retains BPTF in the cytosol. This antibody is a rabbit polyclonal antibody raised against residues near the C terminus of human KEAP1.