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KIF14 Rekombinanter Antikörper

KIF14 Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

243005B8

Kat-Nr. : 85707-1-PBS

Synonyme

Kinesin-like protein KIF14

Filter:
  • Western Blot (WB) analysis of various lysates using KIF14 Recombinant antibody (85707-1-RR)

    WB analysis using 85707-1-RR (same clone as 85707-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 85707-1-RR (KIF14 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85707-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

85707-1-PBS bindet in WB, Indirect ELISA KIF14 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen KIF14 fusion protein Ag23219
Vollständiger Name kinesin family member 14
Beobachtetes Molekulargewicht 186 kDa
GenBank-ZugangsnummerBC113742
Gene symbol KIF14
Gene ID (NCBI) 9928
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

KIF14 (Kinesin Family Member 14) is a microtubule-based motor protein belonging to the kinesin-3 family. It plays essential roles during cell division and has been implicated in various biological processes, including vesicle transport, chromosome segregation, mitotic spindle formation, and cytokinesis. KIF14 is highly conserved across species and is characterized by a catalytic motor domain that binds to microtubules and ATP, enabling it to convert chemical energy into mechanical work. KIF14 interacts with the Skp1/Cul1/F-box (SCF) complex, particularly Skp2 and Cks1, to regulate the ubiquitination and degradation of p27Kip1. Knockdown of KIF14 results in the accumulation of p27Kip1, leading to cell cycle arrest and apoptosis.(PMID: 34131133, PMID: 24854087)