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KIR2DL1 Rekombinanter Antikörper

KIR2DL1 Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

242070D11

Kat-Nr. : 85168-1-PBS

Synonyme

242070D11, CD158 antigen-like family member A, CD158a, Killer cell immunoglobulin-like receptor 2DL1, Natural killer-associated transcript 1

Filter:
  • Western Blot (WB) analysis of various lysates using KIR2DL1 Recombinant antibody (85168-1-RR)

    WB analysis using 85168-1-RR (same clone as 85168-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 85168-1-RR (KIR2DL1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85168-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 85168-1-RR

    Affinity and Kinetic Characterization of 85168-1-RR

    Biolayer interferometry (BLl) kinetic assays of 85168-1-RR against Human KIR2DL1 were performed. The affinity constant is 37.9 nM.

Geprüfte Anwendungen

Produktinformation

85168-1-PBS bindet in WB, Indirect ELISA KIR2DL1 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Rekombinantes Protein
Vollständiger Name killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
Berechnetes Molekulargewicht 39 kDa
Beobachtetes Molekulargewicht45 kDa
GenBank-ZugangsnummerBC069344
Gene symbol KIR2DL1
Gene ID (NCBI) 3802
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Killer cell immunoglobulin-like receptor 2DL1 (KIR2DL1, also known as CD158A and NKAT1) is an inhibitory receptor of NK cells, with β-arrestin 2 mediated recruitment of the tyrosine phosphatases SHP-1 and SHP-2 to KIR2DL1 and facilitated downstream inhibitory signaling (PMID: 18604210). The effector function of NK cells expressing KIR2DL1 or KIR2DS1 is highly influenced by genetic variability and is calibrated by co-expression of additional NK receptors and cognate HLA-C2 ligands (PMID: 31024561).