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KIR2DL3 Polyklonaler Antikörper

KIR2DL3 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 18966-1-PBS

Synonyme

Filter:
  • Western Blot (WB) analysis of human liver tissue using KIR2DL3 Polyclonal antibody (18966-1-AP)

    WB analysis of human liver using 18966-1-AP (same clone as 18966-1-PBS)

    human liver tissue were subjected to SDS PAGE followed by western blot with 18966-1-AP (KIR2DL3 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 18966-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

18966-1-PBS bindet in WB, Indirect ELISA KIR2DL3 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen KIR2DL3 fusion protein Ag5163
Vollständiger Name killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
Berechnetes Molekulargewicht 341 aa, 38 kDa
Beobachtetes Molekulargewicht 58 kDa
GenBank-ZugangsnummerBC032422
Gene symbol KIR2DL3
Gene ID (NCBI) 3804
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Killer cell immunoglobulin-like receptors (KIRs) are a diverse family of inhibitory and activating receptors expressed on NK cells and a subset of T cells (PMID: 11861603). These polymorphic receptors interact with specific motifs on HLA class I molecules, modulate NK cytolytic activity and are encoded by genes located on chromosome 19q13.4 (PMID: 17069649). KIR2DL3, also known as CD158B2 or NKAT2, is an inhibitory receptor that is specific for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7) (PMID: 10196125). It is a 341-amino acid transmembrane glycoprotein consisting of an extracellular region containing two C2-type Ig-like domains, a 19-amino acid hydrophobic transmembrane region, and a long cytoplasmic tail with two immunoreceptor tyrosine-based inhibitory motifs (ITIMs). KIR2DL3 inhibits the cytolytic activity of NK cells thus preventing cell lysis (PMID: 7724594).