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KIR2DL3/CD158b2 Rekombinanter Antikörper

KIR2DL3/CD158b2 Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

242282E11

Kat-Nr. : 98373-3-PBS

Synonyme

KIR2DL3, Killer cell immunoglobulin-like receptor 2DL3, GL183, CD158B2, CD158b

Filter:
  • Flow cytometry (FC) experiment of human PBMCs using Anti-Human KIR2DL3/CD158b2 Rabbit Recombinant Anti (98373-3-RR)

    FC experiment of human PBMCs using 98373-3-RR (same clone as 98373-3-PBS)

    1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human KIR2DL3/CD158b2 Rabbit RecAb (98373-3-RR, Clone: 242282E11) or Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were then stained with CoraLite® Plus 647 Anti-Human NCAM1/CD56. Cells were not fixed. Lymphocytes were gated. This data was developed using the same antibody clone with 98373-3-PBS in a different storage buffer formulation.

  • Flow cytometry (FC) experiment of human PBMCs using Anti-Human KIR2DL3/CD158b2 Rabbit Recombinant Anti (98373-3-RR)

    FC experiment of human PBMCs using 98373-3-RR (same clone as 98373-3-PBS)

    1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human KIR2DL3/CD158b2 Rabbit RecAb (98373-3-RR, Clone: 242282E11) or Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. Lymphocytes were gated. This data was developed using the same antibody clone with 98373-3-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

98373-3-PBS bindet in FC KIR2DL3/CD158b2 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Rekombinantes Protein
Vollständiger Name killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
Berechnetes Molekulargewicht38 kDa
GenBank-ZugangsnummerNM_015868.2
Gene symbol KIR2DL3
Gene ID (NCBI) 3804
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C.

Hintergrundinformationen

Killer cell immunoglobulin-like receptors (KIRs) are a diverse family of inhibitory and activating receptors expressed on NK cells and a subset of T cells (PMID: 11861603). These polymorphic receptors interact with specific motifs on HLA class I molecules, modulate NK cytolytic activity and are encoded by genes located on chromosome 19q13.4 (PMID: 17069649). KIR2DL3, also known as CD158B2 or NKAT2, is an inhibitory receptor that is specific for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7) (PMID: 10196125). It is a 341-amino acid transmembrane glycoprotein consisting of an extracellular region containing two C2-type Ig-like domains, a 19-amino acid hydrophobic transmembrane region, and a long cytoplasmic tail with two immunoreceptor tyrosine-based inhibitory motifs (ITIMs). KIR2DL3 inhibits the cytolytic activity of NK cells thus preventing cell lysis (PMID: 7724594).