KLF2 Polyklonaler Antikörper

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• KD/KO Validated

KLF2 Polyklonal Antikörper für WB, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus

Anwendung

WB, IP, CoIP, ChIP, ELISA

Konjugation

Unkonjugiert

Publikationen(7)

Kat-Nr. : 23384-1-AP

Synonyme

Krueppel like factor 2, Krueppel-like factor 2, Kruppel like factor 2 (lung), LKLF, Lung krueppel like factor

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  WB analysis using 23384-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 23384-1-AP (KLF2 antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in WB: HepG2-Zellen, bEnd.3-Zellen

Empfohlene Verdünnung

• Western Blot (WB): WB : 1:500-1:1000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Veröffentlichte Anwendungen

• WB: See 5 publications below
• IP: See 1 publications below
• CoIP: See 1 publications below
• ChIP: See 2 publications below

Produktinformation

23384-1-AP bindet in WB, IP, CoIP, ChIP, ELISA KLF2 und zeigt Reaktivität mit human, Maus

• Getestete Reaktivität: human, Maus
• In Publikationen genannte Reaktivität: human, Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: KLF2 fusion protein Ag20019
• Vollständiger Name: Kruppel-like factor 2 (lung)
• Berechnetes Molekulargewicht: 355 aa, 37 kDa
• Beobachtetes Molekulargewicht: 37-40 kDa, 60 kDa
• GenBank-Zugangsnummer: BC071983
• Gene symbol: KLF2
• Gene ID (NCBI): 10365
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-affinitätsgereinigt
• Lagerungspuffer: PBS with 0.02% sodium azide and 50% glycerol
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

KLF2 (Kruppel-like Factor 2) belongs to zinc finger transcription factors, and it is implicated in a variety of biochemical processes, including lung development, embryonic erythropoiesis, epithelial integrity, T-cell viability, and adipogenesis (PMID: 17904406). KLF2 was identified as a negative regulator of T cell activation and adipogenesis. KLF2 also acts as a novel regulator of endothelial proinflammatory activation, inhibiting the inflammatory cytokine-mediated induction of adhesion molecule expression and immune cell adhesion (PMID:15718498). KLF2-null mice exhibit abnormal blood vessel formation, resulting in embryonic haemorrhage and death (PMID: 32132543). KLF2 can be detected 60 kDa by post-translationally modified (PMID: 36466816).

Publikationen

Species	Application	Title
human	WB,IP	J Thromb Haemost; IKKβ regulates endothelial thrombomodulin in a Klf2-dependent manner.; Authors - R Pathak
human	ChIP	J Cardiothorac Surg; Mechanism of KLF2 in young mice with pneumonia induced by Streptococcus pneumoniae; Authors - Xiaoshuang Li
mouse,human	WB	Drug Dev Res; KLF2 Inhibits Ferroptosis and Improves Mitochondrial Dysfunction in Chondrocyte Through SIRT1/GPX4 Signaling to Improve Osteoarthritis; Authors - Jiaqi Shi
human	WB	J Cell Mol Med; Single-cell and spatial transcriptomics reveal apelin/APJ pathway's role in microvessel formation and tumour progression in hepatocellular carcinoma; Authors - Yongfu Zhu
human	WB,CoIP	J Orthop Surg Res; A novel mechanism in regulating drug sensitivity, growth, and apoptosis of bortezomib-resistant multiple myeloma cells: the USP4/KLF2/HMGA2 cascade; Authors - Ziyi Liu
human	WB	Theranostics; Deciphering single-cell landscape unravels cell-type-specific functional roles of RNA m6A modification in atherosclerosis; Authors - Xiaorui Ping