KLHDC3 Polyklonaler Antikörper

KLHDC3 Polyklonal Antikörper für IHC, IF/ICC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus

Anwendung

IHC, IF/ICC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 13905-1-PBS

Synonyme

PEAS, Kelch domain-containing protein 3, hPEAS

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  IHC staining of mouse testis using 13905-1-AP (same clone as 13905-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse testis tissue slide using 13905-1-AP (KLHDC3 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 13905-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse testis using 13905-1-AP (same clone as 13905-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse testis tissue slide using 13905-1-AP (KLHDC3 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 13905-1-PBS in a different storage buffer formulation.

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  IHC staining of human testis using 13905-1-AP (same clone as 13905-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human testis tissue slide using 13905-1-AP (KLHDC3 Antibody) at dilution of 1:50 (under 40x lens). This data was developed using the same antibody clone with 13905-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human testis using 13905-1-AP (same clone as 13905-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human testis tissue slide using 13905-1-AP (KLHDC3 Antibody) at dilution of 1:50 (under 10x lens). This data was developed using the same antibody clone with 13905-1-PBS in a different storage buffer formulation.

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  IF Staining of PC-3 using 13905-1-AP (same clone as 13905-1-PBS)

  Immunofluorescent analysis of (-20°C Ethanol) fixed PC-3 cells using KLHDC3 antibody (13905-1-AP) at dilution of 1:400 and Multi-rAb CoraLite ® Plus 488-Goat Anti-Rabbit Recombinant Secondary Antibody (H+L) (RGAR002). This data was developed using the same antibody clone with 13905-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

13905-1-PBS bindet in IHC, IF/ICC, Indirect ELISA KLHDC3 und zeigt Reaktivität mit human, Maus

• Getestete Reaktivität: human, Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: KLHDC3 fusion protein Ag4879
• Vollständiger Name: kelch domain containing 3
• Berechnetes Molekulargewicht: 382 aa, 43 kDa
• GenBank-Zugangsnummer: BC041793
• Gene symbol: KLHDC3
• Gene ID (NCBI): 116138
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

The BTB (Broad-Complex, Tramtrack and Bric a brac) domain, also known as the POZ (Poxvirus and Zinc finger) domain, is an N-terminal homodimerization domain that contains multiple copies of kelch repeats and/or C2H2-type zinc fingers. Proteins that contain BTB domains are thought to be involved in transcriptional regulation via control of chromatin structure and function. The Kelch domain-containing protein 3 (KLHDC3), also designated PEAS, contains 5 Kelch repeats and may be involved in meiotic recombination process. The gene encoding KLHDC3 maps to chromosome 6, which contains around 1,200 genes within 170 million base pairs of sequence. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer suggesting the presence of a cancer susceptibility locus. Porphyria cutanea tarda, Parkinson's disease, Stickler syndrome, 21-hydroxylase deficiency and maple syrup urine disease are also associated with genes on chromosome 6. KLHDC3 protein is mainly expressed in cytoplasm, also found in meiotic chromatin.