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L-Myc Polyklonaler Antikörper

L-Myc Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 14584-1-PBS

Synonyme

Filter:
  • Western Blot (WB) analysis of various lysates using L-Myc Polyclonal antibody (14584-1-AP)

    WB analysis using 14584-1-AP (same clone as 14584-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 14584-1-AP (L-Myc antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 14584-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

14584-1-PBS bindet in WB, Indirect ELISA L-Myc und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen L-Myc fusion protein Ag6105
Vollständiger Name v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)
Berechnetes Molekulargewicht 40 kDa
Beobachtetes Molekulargewicht68 kDa
GenBank-ZugangsnummerBC011864
Gene symbol MYCL1
Gene ID (NCBI) 4610
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

The MYC gene family consists of 3 members, C-MYC, L-MYC, and N-MYC, all of which belong to the superfamily of basic helix-loop-helix leucine zipper (bHLHLZ) DNA binding proteins. L-MYC encodes a nuclear phosphoprotein with 364 amino acids, heterodimerizing with partner protein Max and acts as a transcription factor to control the expression of target genes. L-Myc is involved in many biological processes, including cell proliferation, differentiation, apoptosis and has been found to be amplified and over-expressed in some malignancies. L-Myc amplification has been reported in small-cell lung cancer (PMID: 25528583, 33524794). The observed molecular weight of L-Myc is 68 kDa, which is consistent with the description in the literature (PMID: 8657155).