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L1CAM/CD171 Polyklonaler Antikörper

L1CAM/CD171 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 20659-1-PBS

Synonyme

L1CAM, CAML1, CD171, HSAS, HSAS1

Filter:
  • Western Blot (WB) analysis of various lysates using L1CAM/CD171 Polyclonal antibody (20659-1-AP)

    WB analysis using 20659-1-AP (same clone as 20659-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 20659-1-AP (L1CAM antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 20659-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

20659-1-PBS bindet in WB, Indirect ELISA L1CAM/CD171 und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen Peptid
Vollständiger Name L1 cell adhesion molecule
Berechnetes Molekulargewicht 140 kDa
Beobachtetes Molekulargewicht 200-220 kDa, 80 kDa
GenBank-ZugangsnummerNM_000425
Gene symbol L1CAM
Gene ID (NCBI) 3897
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

L1CAM, also known as NCAM-L1 or CD171, is a cell adhesion molecule of the immunoglobulin superfamily. It is a 200-220 kDa transmembrane glycoprotein composed of six Ig-like domains and five fibronectin type III repeats followed by a transmembrane region and a highly conserved cytoplasmic tail (PMID: 3412448; 22796939). L1CAM is primarily expressed in the nervous system and is involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, cerebellar granule cell migration, neurite outgrowth on Schwann cells and interactions among epithelial cells of intestinal crypts (PMID: 3412448; 10767310). L1CAM is overexpressed in many human cancers and is often associated with bad prognosis (PMID: 27267927; 26111503). It has been reported that L1CAM can be proteolytically cleaved into a soluble fragment of 140 kDa and an intracellular fragment of 80-85 kDa (PMID: 30842511; 34380733). This antibody raised against 1206-1221aa of human L1CAM detects 200-220 kDa full-length L1CAM and 80-kDa cleaved fragment of L1CAM.