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LAG-3/CD223 Rekombinanter Antikörper

LAG-3/CD223 Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

243086D9

Kat-Nr. : 80855-7-PBS

Synonyme

CD223, LAG3, FDC, LAG 3, LAG-3

Filter:
  • Western Blot (WB) analysis of HuT 78 cells using LAG-3/CD223 Recombinant antibody (80855-7-RR)

    WB analysis of HuT 78 using 80855-7-RR (same clone as 80855-7-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 80855-7-RR (LAG3 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 80855-7-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

80855-7-PBS bindet in WB, Indirect ELISA LAG-3/CD223 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen LAG-3/CD223 fusion protein Eg31550
Vollständiger Name lymphocyte-activation gene 3
Berechnetes Molekulargewicht57 kDa
Beobachtetes Molekulargewicht70 kDa
GenBank-ZugangsnummerNM_002286
Gene symbol LAG-3
Gene ID (NCBI) 3902
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

LAG-3, also known as CD223, is an immune checkpoint molecule that regulates both T-cell activation and homeostasis. LAG-3 is expressed on activated T cells, NK cells, regulatory T cells, and plasmacytoid dendritic cells. It is a CD4-related molecule that binds MHC class II. LAG-3 plays an important role in modulating T cell expansion and function, and blockade of LAG-3 with monoclonal antibodies can augment T cell function. (PMID: 15634887; 21086108; 28783703)