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LAG-3/CD223 Rekombinanter Antikörper

LAG-3/CD223 Rekombinant Antikörper für IHC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

Maus

Anwendung

IHC, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

241007B1

Kat-Nr. : 83941-7-PBS

Synonyme

CD223, LAG-3, LAG 3, Lag3, Ly66

Filter:
  • Immunohistochemistry (IHC) staining of mouse spleen tissue using LAG-3/CD223 Recombinant monoclonal antibody (83941-7-RR)

    IHC staining of mouse spleen using 83941-7-RR (same clone as 83941-7-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse spleen tissue slide using 83941-7-RR (LAG-3/CD223 antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 83941-7-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of mouse spleen tissue using LAG-3/CD223 Recombinant monoclonal antibody (83941-7-RR)

    IHC staining of mouse spleen using 83941-7-RR (same clone as 83941-7-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse spleen tissue slide using 83941-7-RR (LAG-3/CD223 antibody) at dilution of 1:1000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 83941-7-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 83941-7-PBS

    Affinity and Kinetic Characterization of 83941-7-PBS

    Biolayer interferometry (BLl) kinetic assay of 83941-7-PBS against Mouse LAG-3/CD223 was performed. The affinity constant is 61.3 nM.

Geprüfte Anwendungen

Produktinformation

83941-7-PBS bindet in IHC, Indirect ELISA LAG-3/CD223 und zeigt Reaktivität mit Maus

Getestete Reaktivität Maus
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen LAG-3/CD223 fusion protein Eg1220
Vollständiger Name lymphocyte-activation gene 3
Berechnetes Molekulargewicht57 kDa
GenBank-ZugangsnummerNM_008479.2
Gene symbol CD223
Gene ID (NCBI) 16768
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

LAG-3, also known as CD223, is an immune checkpoint molecule that regulates both T-cell activation and homeostasis. LAG-3 is expressed on activated T cells, NK cells, regulatory T cells, and plasmacytoid dendritic cells. It is a CD4-related molecule that binds MHC class II. LAG-3 plays an important role in modulating T cell expansion and function, and blockade of LAG-3 with monoclonal antibodies can augment T cell function. (PMID: 15634887; 21086108; 28783703)