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LAIR1 Rekombinanter Antikörper

LAIR1 Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

Maus

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

242226E10

Kat-Nr. : 98286-1-PBS

Synonyme

mLAIR1, Leukocyte-associated immunoglobulin-like receptor 1, LAIR-1, CD305, 242226E10

Filter:
  • Flow cytometry (FC) experiment of mouse splenocytes using Anti-Mouse LAIR1 Rabbit Recombinant Antibody (98286-1-RR)

    FC experiment of mouse splenocytes using 98286-1-RR (same clone as 98286-1-PBS)

    1x10^6 mouse splenocytes were surface stained with 0.13 ug Anti-Mouse LAIR1 Rabbit RecAb (98286-1-RR, Clone:242226E10) or 0.13 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98286-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98286-1-RR

    Affinity and Kinetic Characterization of 98286-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98286-1-RR against Mouse LAIR1 were performed. The affinity constant is 0.739 nM.

Geprüfte Anwendungen

Produktinformation

98286-1-PBS bindet in FC LAIR1 und zeigt Reaktivität mit Maus

Getestete Reaktivität Maus
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Rekombinantes Protein
Vollständiger Name leukocyte-associated Ig-like receptor 1
Berechnetes Molekulargewicht30kDa
GenBank-ZugangsnummerNM_001113474.1
Gene symbol Lair1
Gene ID (NCBI) 52855
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C.

Hintergrundinformationen

Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1) is a transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs (PMID: 9285412). LAIR1 is expressed on the majority of human PBMCs, including NK, T, B, monocytes, and dendritic cells, as well as the majority of thymocytes (PMID: 10229813). It functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of NK cells, B cells and T cells. LAIR1 is a collagen receptor (PMID: 16754721). Tumor-expressed collagens can modulate immune cell function through the inhibitory collagen receptor LAIR1 (PMID: 21955987).