LAIR1 Rekombinanter Antikörper

LAIR1 Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

Maus

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

242226E10

Kat-Nr. : 98286-1-RR

Synonyme

mLAIR1, Leukocyte-associated immunoglobulin-like receptor 1, LAIR-1, CD305, 242226E10

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  FC experiment of mouse splenocytes using 98286-1-RR

  1x10^6 mouse splenocytes were surface stained with 0.13 ug Anti-Mouse LAIR1 Rabbit RecAb (98286-1-RR, Clone:242226E10) or 0.13 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed.

• 

  Affinity and Kinetic Characterization of 98286-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98286-1-RR against Mouse LAIR1 were performed. The affinity constant is 0.739 nM.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in FC: Maus-Splenozyten

Empfohlene Verdünnung

Anwendung	Verdünnung
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Produktinformation

98286-1-RR bindet in FC LAIR1 und zeigt Reaktivität mit Maus

• Getestete Reaktivität: Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: Rekombinantes Protein
• Vollständiger Name: leukocyte-associated Ig-like receptor 1
• Berechnetes Molekulargewicht: 30kDa
• GenBank-Zugangsnummer: NM_001113474.1
• Gene symbol: Lair1
• Gene ID (NCBI): 52855
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein A purfication
• Lagerungspuffer: PBS with 0.09% sodium azide
• Lagerungsbedingungen: Store at 2 - 8°C. Stable for one year after shipment.

Hintergrundinformationen

Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1) is a transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs (PMID: 9285412). LAIR1 is expressed on the majority of human PBMCs, including NK, T, B, monocytes, and dendritic cells, as well as the majority of thymocytes (PMID: 10229813). It functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of NK cells, B cells and T cells. LAIR1 is a collagen receptor (PMID: 16754721). Tumor-expressed collagens can modulate immune cell function through the inhibitory collagen receptor LAIR1 (PMID: 21955987).