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LATS1 Polyklonaler Antikörper

LATS1 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 30174-1-PBS

Synonyme

Filter:
  • Western Blot (WB) analysis of various lysates using LATS1 Polyclonal antibody (30174-1-AP)

    WB analysis using 30174-1-AP (same clone as 30174-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 30174-1-AP (LATS1 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 30174-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of various lysates using LATS1 Polyclonal antibody (30174-1-AP)

    WB analysis using 30174-1-AP (same clone as 30174-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 30174-1-AP (LATS1 antibody) at dilution of 1:7000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 30174-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

30174-1-PBS bindet in WB, Indirect ELISA LATS1 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen LATS1 fusion protein Ag32879
Vollständiger Name LATS, large tumor suppressor, homolog 1 (Drosophila)
Beobachtetes Molekulargewicht130 kDa
GenBank-ZugangsnummerBC002767
Gene symbol LATS1
Gene ID (NCBI) 9113
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

LATS1(Large tumor suppressor homolog 1) is also named as WARTS and belongs to the AGC Ser/Thr protein kinase family. The gene encodes a highly conserved (from fly to human) protein kinase that plays a crucial role in the prevention of tumor formation by controlling the progression of mitosis. The expression of both long(170 kDa) and short lats1 isoforms(120 kDa) in vertebrate retinal cells raises the possibility that these lats1 proteins may act as negative key regulators of the cell cycle each of them performing a unique role (PMID:15777619). In mammalian cells, LATS1 was phosphorylated in a cell cycle-dependent manner and complexed with CDC2 in early mitosis (PMID:9988268). LATS1 also can be detected as 120 kDa and 140-150 kDa, and play a key role in the regulation of Hippo pathway (PMID: 27940445).