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LEPR Rekombinanter Antikörper

LEPR Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

241692G9

Kat-Nr. : 84464-4-PBS

Synonyme

LEP-R, LEP R, HuB219, DB, CD295

Filter:
  • Western Blot (WB) analysis of various lysates using LEPR Recombinant antibody (84464-4-RR)

    WB analysis using 84464-4-RR (same clone as 84464-4-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84464-4-RR (LEPR antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84464-4-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

84464-4-PBS bindet in WB, Indirect ELISA LEPR und zeigt Reaktivität mit human, Maus

Getestete Reaktivität human, Maus
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Rekombinantes Protein
Vollständiger Name leptin receptor
Berechnetes Molekulargewicht 132 kDa
Beobachtetes Molekulargewicht120 kDa
GenBank-ZugangsnummerNM_002303
Gene symbol LEPR
Gene ID (NCBI) 3953
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

The hormone leptin, secreted predominantly from adipose tissue, plays a crucial role in the regulation of numerous neuroendocrine functions, from energy homeostasis to reproduction (PMID: 22249808). Leptin acts through the leptin receptor (LEPR, also known as OB-R), a single-transmembrane-domain receptor of the cytokine receptor family. On ligand binding, LEPR mediates signaling through JAK2/STAT3 (PMID: 9102398). LEPR plays an important role in the regulation of glucose homeostasis via feeding and adiposity. Alternatively spliced transcript variants encoding different isoforms of LEPR have been described.