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LIFR Rekombinanter Antikörper

LIFR Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

250110B11

Kat-Nr. : 85827-2-PBS

Synonyme

CD118, LIF R, LIF receptor, LIF-R, SJS2

Filter:
  • Western Blot (WB) analysis of various lysates using LIFR Recombinant antibody (85827-2-RR)

    WB analysis using 85827-2-RR (same clone as 85827-2-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 85827-2-RR (LIFR antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85827-2-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

85827-2-PBS bindet in WB, Indirect ELISA LIFR und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen LIFR fusion protein Eg2599
Vollständiger Name leukemia inhibitory factor receptor alpha
Berechnetes Molekulargewicht124 kDa
Beobachtetes Molekulargewicht190 kDa, 170 kDa
GenBank-ZugangsnummerNM_001127671.1
Gene symbol LIFR
Gene ID (NCBI) 3977
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

LIFR, also known as CD118, is a subunit of a receptor for leukemia inhibitory factor (LIF). LIF is a pleiotropic cytokine of the interleukin-6 family that affects the differentiation, survival, and proliferation of a wide variety of cells in the adult and the embryo. LIFR is the low-affinity binding chain that, together with the high-affinity converter subunit gp130, forms a high-affinity receptor complex that mediates the action of LIF. The high-affinity complex also binds a related cytokine, oncostatin M (PMID: 8999038). LIFR has also been identified as a breast cancer metastasis suppressor that functions through the HIPPO-YAP pathway (PMID: 23001183). LIFR appeared as doublets with 190 and 170 kDa (PMID: 10858440). They represented different glycosylated forms of the LIFR in different steps of protein maturation.