LILRB2/CD85d Rekombinanter Antikörper

LILRB2/CD85d Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

250299A6

Kat-Nr. : 98488-3-PBS

Synonyme

LILRB2, CD85 antigen-like family member D, CD85d, ILT 4, ILT4

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  FC experiment of human PBMCs using 98488-3-RR (same clone as 98488-3-PBS)

  1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human LILRB2/CD85d Rabbit RecAb (98488-3-RR, Clone:250299A6) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98488-3-PBS in a different storage buffer formulation.

• 

  FC experiment of human PBMCs using 98488-3-RR (same clone as 98488-3-PBS)

  1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human LILRB2/CD85d Rabbit RecAb (98488-3-RR, Clone: 250299A6) (red) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98488-3-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

98488-3-PBS bindet in FC LILRB2/CD85d und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: LILRB2/CD85d fusion protein Eg2839
• Vollständiger Name: leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
• Berechnetes Molekulargewicht: 65 kDa
• GenBank-Zugangsnummer: NM_005874.4
• Gene symbol: LILRB2
• Gene ID (NCBI): 10288
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C.

Hintergrundinformationen

LILRB2 (Leukocyte immunoglobulin-like receptor subfamily B member 2), also known as ILT4, CD85d or MIR10, is a type I transmembrane glycoprotein that contains four extracellular immunoglobulin domains, a transmembrane domain, and three cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs) (PMID: 33928233). LILRB2 is mainly expressed in immunocytes including monocytes, macrophages, and dendritic cells, and transduces negative signals by its association with SHP-1 phosphatase via the ITIMs (PMID: 35717259). LILRB2 can interact with various ligands such as HLA-A, HLA-B, HLA-C, HLA-G, HLA-F, CD1c, CD1d, angiopoietin-like proteins (ANGPTLs), and SEMA4A.