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LILRB3 Polyklonaler Antikörper

LILRB3 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 18260-1-PBS

Synonyme

Filter:
  • Western Blot (WB) analysis of various lysates using LILRB3 Polyclonal antibody (18260-1-AP)

    WB analysis using 18260-1-AP (same clone as 18260-1-PBS)

    human peripheral blood leukocyte were subjected to SDS PAGE followed by western blot with 18260-1-AP (LILRB3 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 18260-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

18260-1-PBS bindet in WB, Indirect ELISA LILRB3 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen LILRB3 fusion protein Ag13110
Vollständiger Name leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
Berechnetes Molekulargewicht 631 aa, 69 kDa
Beobachtetes Molekulargewicht80-90 kDa
GenBank-ZugangsnummerBC112198
Gene symbol LILRB3
Gene ID (NCBI) 11025
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

The leukocyte immunoglobulin-like receptors (LIRs, also known as ILTs, CD85, and LILRs) comprise a family of related immunoregulatory receptors encoded within the leukocyte receptor cluster (LRC) at chromosomal region 19q13.4 (PMID: 11491530). LIRs are transmembrane proteins containing either two or four extracellular immunoglobulin domains, and have diverse functions, including the regulation of inflammation, immune tolerance, cell differentiation and nervous system plasticity (PMID: 16406677; 26040207). LILRB3, also known as ILT-5 or CD85a, belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). LILRB3 is found on the surface of a variety of cell types including monocytes/macrophages, granulocytes, NK cells and some T cells. It binds to MHC class I molecules and transduces a negative signal that inhibits stimulation of an immune response. LILRB3 has been reported as a myeloid cell checkpoint that elicits profound immunomodulation (PMID: 32870822).