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LLGL1 Polyklonaler Antikörper

LLGL1 Polyklonal Antikörper für WB, IF/ICC, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, IF/ICC, ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 22496-1-PBS

Synonyme

lethal giant larvae homolog 1 (Drosophila), Hugl-1, Hugl1

Filter:
  • Western Blot (WB) analysis of various lysates using LLGL1 Polyclonal antibody (22496-1-AP)

    WB analysis using 22496-1-AP (same clone as 22496-1-PBS)

    A431 cells were subjected to SDS PAGE followed by western blot with 22496-1-AP (LLGL1 antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 22496-1-PBS in a different storage buffer formulation.

  • Immunofluorescence (IF) / fluorescent staining of HepG2 cells using LLGL1 Polyclonal antibody (22496-1-AP)

    IF Staining of HepG2 using 22496-1-AP (same clone as 22496-1-PBS)

    Immunofluorescent analysis of (-20°C Ethanol) fixed HepG2 cells using LLGL1 antibody (22496-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 22496-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

22496-1-PBS bindet in WB, IF/ICC, ELISA LLGL1 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen LLGL1 fusion protein Ag18057
Vollständiger Name lethal giant larvae homolog 1 (Drosophila)
Berechnetes Molekulargewicht 1064 aa, 115 kDa
Beobachtetes Molekulargewicht115 kDa
GenBank-ZugangsnummerBC151838
Gene symbol LLGL1
Gene ID (NCBI) 3996
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-affinitätsgereinigt
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Lethal giant larvae (Lgl) is a scaffolding protein that regulates the establishment of apical-basal polarity in epithelial cells. The human homologs of Lgl are known as LLGL1 and LLGL2. LLGL1 is a tumor suppressor in multiple human cancers, including hepatocellular carcinoma, malignant melanoma, and colorectal cancer (PMID: 34178676; 15735678; 16170365). LLGL2 functions as a promoter of tumor growth and not as a tumor suppressor in ER+ breast cancer (PMID: 30996345).