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LPXN Polyklonaler Antikörper

LPXN Polyklonal Antikörper für WB, IF/ICC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus

Anwendung

WB, IF/ICC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 31231-1-PBS

Synonyme

LDPL, LDLP

Filter:
  • Western Blot (WB) analysis of various lysates using LPXN Polyclonal antibody (31231-1-AP)

    WB analysis using 31231-1-AP (same clone as 31231-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 31231-1-AP (LPXN antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 31231-1-PBS in a different storage buffer formulation.

  • Immunofluorescence (IF) / fluorescent staining of A549 cells using LPXN Polyclonal antibody (31231-1-AP)

    IF Staining of A549 using 31231-1-AP (same clone as 31231-1-PBS)

    Immunofluorescent analysis of (-20°C Methanol) fixed A549 cells using LPXN antibody (31231-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 31231-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

31231-1-PBS bindet in WB, IF/ICC, Indirect ELISA LPXN und zeigt Reaktivität mit human, Maus

Getestete Reaktivität human, Maus
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen LPXN fusion protein Ag34956
Vollständiger Name leupaxin
Berechnetes Molekulargewicht 43 kDa
Beobachtetes Molekulargewicht 40-50 kDa
GenBank-ZugangsnummerBC019035
Gene symbol LPXN
Gene ID (NCBI) 9404
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

LPXN, also known as Leupaxin, LDPL, belongs to the paxillin family. LPXN Contributes to the regulation of cell adhesion, spreading, and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events (PMID: 20543562). LPXN has four leucine-rich LD-motifs in the N-terminus and four LIM domains in the C-terminus. It may function in cell type-specific signaling by associating with PYK2, a member of the focal adhesion kinase family (PMID: 9565592). Studies in breast cancer implicate LPXN is involved in the regulation of ER action as a co-factor (PMID: 25955236). LPXN is expressed in prostate cancer cells and its expression intensity is directly linked to PCa progression (PMID: 18451096).