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LRAT Rekombinanter Antikörper

LRAT Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

243058B5

Kat-Nr. : 85628-1-PBS

Synonyme

EC:2.3.1.135, Lecithin retinol acyltransferase, Phosphatidylcholine--retinol O-acyltransferase

Filter:
  • Western Blot (WB) analysis of various lysates using LRAT Recombinant antibody (85628-1-RR)

    WB analysis using 85628-1-RR (same clone as 85628-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 85628-1-RR (LRAT antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85628-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 85628-1-RR

    Affinity and Kinetic Characterization of 85628-1-RR

    Biolayer interferometry (BLl) kinetic assays of 85628-1-RR against Human LRAT were performed. The affinity constant is below 1 pM.

Geprüfte Anwendungen

Produktinformation

85628-1-PBS bindet in WB, Indirect ELISA LRAT und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen LRAT fusion protein Ag3556
Vollständiger Name lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
Berechnetes Molekulargewicht 230 aa, 26 kDa
Beobachtetes Molekulargewicht 26 kDa, 50-54 kDa
GenBank-ZugangsnummerBC031053
Gene symbol LRAT
Gene ID (NCBI) 9227
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

LRAT belongs to the H-rev107 family. LRAT transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. LRAT plays a critical role in vision. It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, LRAT monomers (26kDa) interact in membranes and form functional homodimers (50-54 kDa) through protein-protein interactions and disulfide bond formation.Defects in LRAT are a cause of severe early-onset retinal dystrophy (RD). This antibody was generated against the internal residues of human LRAT. It is predicted to detect endogenous LRAT.