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LRFN2 Polyklonaler Antikörper

LRFN2 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 27576-1-PBS

Synonyme

FIGLER2, KIAA1246, RP11 535K1.2, SALM1

Filter:
  • Western Blot (WB) analysis of various lysates using LRFN2 Polyclonal antibody (27576-1-AP)

    WB analysis using 27576-1-AP (same clone as 27576-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 27576-1-AP (LRFN2 antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 27576-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

27576-1-PBS bindet in WB, Indirect ELISA LRFN2 und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen LRFN2 fusion protein Ag24558
Vollständiger Name leucine rich repeat and fibronectin type III domain containing 2
Berechnetes Molekulargewicht 789 aa, 85 kDa
Beobachtetes Molekulargewicht85-100 kDa
GenBank-ZugangsnummerBC142616
Gene symbol LRFN2
Gene ID (NCBI) 57497
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

LRFN2, also known as SALM1. It is mainly located in cell membrane and cytoplasm, and it is expressed at the synaptic contact at the base of cone cells, especially at the base of presynaptic endings, which is closely related to the dendrites of OFF bipolar cells (PMID: 40251167). In mammals, LRFN2 is mainly expressed in cone cells, but not in rod cells, and its expression in other retinal neurons is limited. In addition, the expression level in embryonic nerve cells is relatively low, mainly in more mature cells. LRFN2 plays a key role in synaptic transmission between cone cells and OFF bipolar cells. It can maintain the physical connection between cone cells and OFF bipolar cells, and gather glutamate receptors at the postsynaptic membrane to ensure strong dendritic transmission in OFF pathway, thus participating in the transmission of visual signals, which is very important for the coding of visual contrast and the defense behavior driven by looming. In bladder cancer, the increased expression of LRFN2 will inhibit the infiltration and functional transformation of CD8+ T cells, thus weakening the anti-tumor immune response, leading to bladder cancer resistance to immune checkpoint inhibitors, and its high expression is related to the poor prognosis of bladder cancer patients (PMID:37802603).