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LRP1 Rekombinanter Antikörper

LRP1 Rekombinant Antikörper für FC

Wirt / Isotyp

Maus / IgG2a

Getestete Reaktivität

human

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

5A6

Kat-Nr. : 65594-1-PBS

Synonyme

5A6, A2MR, Alpha 2 macroglobulin receptor, Alpha-2-macroglobulin receptor, APOER

Filter:
  • Flow cytometry (FC) experiment of U-87 MG cells using Anti-Human LRP1 (5A6) Mouse IgG2a Recombinant Anti (65594-1-MR)

    FC experiment of U-87 MG using 65594-1-MR (same clone as 65594-1-PBS)

    1x10^6 U-87 MG cells were surface stained with 0.25 ug Anti-Human LRP1 (5A6) Mouse IgG2a RecAb (65594-1-MR, Clone: 5A6) (red) or Mouse IgG2a Isotype Control (C1.18.4) (65208-1-Ig, Clone: C1.18.4) (blue), and PE-conjugated Goat Anti-Mouse IgG. Cells were not fixed. This data was developed using the same antibody clone with 65594-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

65594-1-PBS bindet in FC LRP1 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Maus / IgG2a
Klonalität Rekombinant
Typ Antikörper
Immunogen Full length native protein (purified)
Vollständiger Name low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)
Berechnetes Molekulargewicht 505 kDa
GenBank-ZugangsnummerBC045107
Gene symbol LRP1
Gene ID (NCBI) 4035
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C.

Hintergrundinformationen

LRP1 (Prolow-density lipoprotein receptor-related protein 1), also known as A2MR, APOER and CD91, is a type I transmembrane protein that belongs to the LDLR family. LRP1 is synthesized as a transmembrane glycosylated precursor of 600 kDa, and is subsequently cleaved to generate a large 515-kDa N-terminal extracellular subunit and an 85-kDa C-terminal transmembrane subunit, which are noncovalently associated with one another (PMID: 2112085; 8546712). LRP1 is a multifunctional receptor involved in the clearance of a large number of diverse ligands and modulating various cellular processes. LRP1 is implicated in conditions such as atherosclerosis, cancer and neurodegenerative diseases (PMID: 28381441).