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LRP4 Polyklonaler Antikörper

LRP4 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 24434-1-PBS

Synonyme

MEGF7, LRP-4, LRP10, LRP 4, Low-density lipoprotein receptor-related protein 4

Filter:
  • Western Blot (WB) analysis of various lysates using LRP4 Polyclonal antibody (24434-1-AP)

    WB analysis using 24434-1-AP (same clone as 24434-1-PBS)

    Mouse brain tissue was subjected to SDS PAGE followed by western blot with 24434-1-AP (LRP4 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 24434-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

24434-1-PBS bindet in WB, Indirect ELISA LRP4 und zeigt Reaktivität mit human, Maus

Getestete Reaktivität human, Maus
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen LRP4 fusion protein Ag19487
Vollständiger Name low density lipoprotein receptor-related protein 4
Berechnetes Molekulargewicht 1905 aa, 212 kDa
Beobachtetes Molekulargewicht240 kDa
GenBank-ZugangsnummerBC136667
Gene symbol LRP4
Gene ID (NCBI) 4038
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

LRP4 (low-density lipoprotein receptor-related protein 4), also known as multiple epidermal growth factor-like domains 7 (MEGF7), is a type I single transmembrane protein of the low-density lipoprotein receptor (LDLR) family. LRP4 is composed of a large extracellular region containing multiple LDLa repeats, EGF-like domains and β-propeller domains, a transmembrane region and a cytoplasmic region containing an NPxY motif and a PDZ-interacting motif (PMID: 26071838). LRP4 binds agrin and recruits it to the MuSK signaling complex, which is critical for neuromuscular junction formation (PMID: 17119023; 18957220). LPR4 mutation or malfunction is implicated in disorders including congenital myasthenic syndrome, myasthenia gravis, and diseases of bone or kidney (26071838).