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LRP4 Rekombinanter Antikörper

LRP4 Rekombinant Antikörper für WB, IF/ICC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, IF/ICC, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

242157D11

Kat-Nr. : 84973-1-PBS

Synonyme

242157D11, KIAA0816, Low-density lipoprotein receptor-related protein 4, LRP 4, LRP10

Filter:
  • Western Blot (WB) analysis of various lysates using LRP4 Recombinant antibody (84973-1-RR)

    WB analysis using 84973-1-RR (same clone as 84973-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84973-1-RR (LRP4 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84973-1-PBS in a different storage buffer formulation.

  • Immunofluorescence (IF) / fluorescent staining of PC-12 cells using LRP4 Recombinant antibody (84973-1-RR)

    IF Staining of PC-12 using 84973-1-RR (same clone as 84973-1-PBS)

    Immunofluorescent analysis of (-20°C Methanol) fixed PC-12 cells using LRP4 antibody (84973-1-RR, Clone: 242157D11 ) at dilution of 1:500 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 84973-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84973-1-RR

    Affinity and Kinetic Characterization of 84973-1-RR

    Biolayer interferometry (BLl) kinetic assays of 84973-1-RR against Human LRP4 were performed. The affinity constant is 70.0 nM.

Geprüfte Anwendungen

Produktinformation

84973-1-PBS bindet in WB, IF/ICC, Indirect ELISA LRP4 und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen LRP4 fusion protein Ag19413
Vollständiger Name low density lipoprotein receptor-related protein 4
Berechnetes Molekulargewicht 1905 aa, 212 kDa
Beobachtetes Molekulargewicht245 kDa
GenBank-ZugangsnummerBC136667
Gene symbol LRP4
Gene ID (NCBI) 4038
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

LRP4 (low-density lipoprotein receptor-related protein 4), also known as multiple epidermal growth factor-like domains 7 (MEGF7), is a type I single transmembrane protein of the low-density lipoprotein receptor (LDLR) family. LRP4 is composed of a large extracellular region containing multiple LDLa repeats, EGF-like domains and β-propeller domains, a transmembrane region and a cytoplasmic region containing an NPxY motif and a PDZ-interacting motif (PMID: 26071838). LRP4 binds agrin and recruits it to the MuSK signaling complex, which is critical for neuromuscular junction formation (PMID: 17119023; 18957220). LPR4 mutation or malfunction is implicated in disorders including congenital myasthenic syndrome, myasthenia gravis, and diseases of bone or kidney (26071838).