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LTBP2 Rekombinanter Antikörper

LTBP2 Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

241911C7

Kat-Nr. : 84574-4-PBS

Synonyme

LTBP3, C14orf141, 241911C7, LTBP-2, LTBP 2

Filter:
  • Western Blot (WB) analysis of various lysates using LTBP2 Recombinant antibody (84574-4-RR)

    WB analysis using 84574-4-RR (same clone as 84574-4-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84574-4-RR (LTBP2 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84574-4-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84574-4-RR

    Affinity and Kinetic Characterization of 84574-4-RR

    Biolayer interferometry (BLl) kinetic assays of 84574-4-RR against Human LTBP2 were performed. The affinity constant is 0.779 nM.

Geprüfte Anwendungen

Produktinformation

84574-4-PBS bindet in WB, Indirect ELISA LTBP2 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen LTBP2 fusion protein Ag29720
Vollständiger Name latent transforming growth factor beta binding protein 2
Berechnetes Molekulargewicht 1821 aa, 195 kDa
Beobachtetes Molekulargewicht290 kDa
GenBank-ZugangsnummerBC078659
Gene symbol LTBP2
Gene ID (NCBI) 4053
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

LTBP2, an extracellular glycoprotein mapping to chromosome 14q24, belongs to a family of latent TGF-β binding proteins (LTBPs) that regulates a well-known growth factor, TGF-β. LTBP2 is an elastic fiber-associating protein whose function in elastogenesis is not clear, as a DANCEbinding Protein. (PMID: 17581631 )It may play an integral structural role in elastic-fiber architectural organization and/or assembly. LTBP2 associates covalently with small latent TGF-beta complex via Repeat B and Repeat C. Defects in LTBP2 are the cause of primary congenital glaucoma type 3D (GLC3D). [MIM:613086] LTBP2 is a role in the structural stability of ciliary zonules, and growth and development of lens.(PMID: 20617341) LTBP2 null mutations in an autosomal recessive ocular syndrome with megalocornea, spherophakia, and secondary glaucoma (PMID: 20179738 ) . LTBP2 is a biomarker of heart failure. LTBP2 has a molecular weight of 260 kDa (PMID: 20878956), and even larger molecular weights of 290 and 310 kDa were detected in tissue extracts. (PMID: 8524260)