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LUC7L2 Polyklonaler Antikörper

LUC7L2 Polyklonal Antikörper für WB, IF/ICC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, IF/ICC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 24202-1-PBS

Synonyme

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  • Western Blot (WB) analysis of K-562 cells using LUC7L2 Polyclonal antibody (24202-1-AP)

    WB analysis of K-562 using 24202-1-AP (same clone as 24202-1-PBS)

    K-562 cells were subjected to SDS PAGE followed by western blot with 24202-1-AP (LUC7L2 Antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 24202-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of HeLa cells using LUC7L2 Polyclonal antibody (24202-1-AP)

    WB analysis of HeLa using 24202-1-AP (same clone as 24202-1-PBS)

    WB result of LUC7L2 antibody (24202-1-AP; 1:1000; incubated at room temperature for 1.5 hours) with sh-Control and sh-LUC7L2 transfected HeLa cells. This data was developed using the same antibody clone with 24202-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of HeLa cells using LUC7L2 Polyclonal antibody (24202-1-AP)

    WB analysis of HeLa using 24202-1-AP (same clone as 24202-1-PBS)

    HeLa cells were subjected to SDS PAGE followed by western blot with 24202-1-AP (LUC7L2 Antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 24202-1-PBS in a different storage buffer formulation.

  • Immunofluorescence (IF) / fluorescent staining of A431 cells using LUC7L2 Polyclonal antibody (24202-1-AP)

    IF Staining of A431 using 24202-1-AP (same clone as 24202-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed A431 cells using LUC7L2 antibody (24202-1-AP) at dilution of 1:600 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L), CL594-Phalloidin (red). This data was developed using the same antibody clone with 24202-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

24202-1-PBS bindet in WB, IF/ICC, Indirect ELISA LUC7L2 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen LUC7L2 fusion protein Ag21135
Vollständiger Name LUC7-like 2 (S. cerevisiae)
Berechnetes Molekulargewicht 392 aa, 47 kDa
Beobachtetes Molekulargewicht 46 kDa
GenBank-ZugangsnummerBC017163
Gene symbol LUC7L2
Gene ID (NCBI) 51631
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-affinitätsgereinigt
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

RNA-binding protein LUC7L2 as a negative regulator of DNA virus-triggered innate immune response. Mechanistically, LUC7L2 directly bound to intron 3 of MITA precursor messenger RNA, inhibited its splicing, and promoted its nonsense-mediated decay, leading to its downregulation at the protein level (PMID:34155193). Moreover, LUC7L2 as a component of the U1 snRNP capable of reprogramming cellular metabolism through changes in alternative pre-mRNA splicing (PMID:33961773).