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Leiomodin-2 Polyklonaler Antikörper

Leiomodin-2 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

Hausschwein, human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 31202-1-PBS

Synonyme

LMOD2, Leiomodin 2, Cardiac leiomodin, C LMOD

Filter:
  • Western Blot (WB) analysis of various lysates using Leiomodin-2 Polyclonal antibody (31202-1-AP)

    WB analysis using 31202-1-AP (same clone as 31202-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 31202-1-AP (LMOD2 antibody) at dilution of 1:15000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 31202-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

31202-1-PBS bindet in WB, Indirect ELISA Leiomodin-2 und zeigt Reaktivität mit Hausschwein, human, Maus, Ratten

Getestete Reaktivität Hausschwein, human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen Leiomodin-2 fusion protein Ag35312
Vollständiger Name leiomodin 2 (cardiac)
Berechnetes Molekulargewicht62 kDa
Beobachtetes Molekulargewicht70-100 kDa
GenBank-ZugangsnummerNM_207163.2
Gene symbol LMOD2
Gene ID (NCBI) 442721
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Leiomodin-2 (Lmod2) is a striated muscle-specific actin-binding protein that plays a crucial role in the regulation of thin filament length and assembly in muscle cells. It is particularly important in cardiac and skeletal muscles. In the heart, Lmod2 is necessary for maintaining proper thin filament length, which is crucial for generating contractile force. Studies have shown that Lmod2 knockout in mice leads to dilated cardiomyopathy and rapid cardiac failure due to shorter and non-uniform thin filaments. Lmod2 is also essential for effective skeletal muscle contraction. Mutations or loss of Lmod2 can lead to significant impairments in muscle function. Mutations in the LMOD2 gene have been linked to severe neonatal and infantile dilated cardiomyopathy, a condition characterized by enlarged heart chambers and impaired contractility. Its observed molecular weight is 70-100 kDa.