MACC1 Polyklonaler Antikörper

MACC1 Polyklonal Antikörper für IHC, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus

Anwendung

IHC, ELISA

Konjugation

Unkonjugiert

Publikationen(2)

Kat-Nr. : 21970-1-AP

Synonyme

7A5, MACC1, SH3BP4L

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  IHC staining of human liver cancer using 21970-1-AP

  Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using 21970-1-AP (MACC1 Antibody) at dilution of 1:50 (under 10x lens).

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  IHC staining of human liver cancer using 21970-1-AP

  Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using 21970-1-AP (MACC1 Antibody) at dilution of 1:50 (under 40x lens).

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  IHC staining of human colon cancer using 21970-1-AP

  Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 21970-1-AP (MACC1 Antibody) at dilution of 1:50 (under 10x lens).

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  IHC staining of human colon cancer using 21970-1-AP

  Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 21970-1-AP (MACC1 Antibody) at dilution of 1:50 (under 40x lens).

• 

  IHC staining of human liver cancer using 21970-1-AP

  Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using 21970-1-AP (MACC1 Antibody) at dilution of 1:50 (under 40x lens).

• 

  IHC staining of human liver cancer using 21970-1-AP

  Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using 21970-1-AP (MACC1 Antibody) at dilution of 1:50 (under 10x lens).

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Geprüfte Anwendungen

• Erfolgreiche Detektion in IHC: humanes Leberkarzinomgewebe, humanes Kolonkarzinomgewebe; Hinweis: Antigendemaskierung mit TE-Puffer pH 9,0 empfohlen. (*) Wahlweise kann die Antigendemaskierung auch mit Citratpuffer pH 6,0 erfolgen.

Empfohlene Verdünnung

• Immunhistochemie (IHC): IHC : 1:20-1:200

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Veröffentlichte Anwendungen

• IHC: See 1 publications below

Produktinformation

21970-1-AP bindet in IHC, ELISA MACC1 und zeigt Reaktivität mit human, Maus

• Getestete Reaktivität: human, Maus
• In Publikationen genannte Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: MACC1 fusion protein Ag16884
• Vollständiger Name: metastasis associated in colon cancer 1
• Berechnetes Molekulargewicht: 852 aa, 97 kDa
• GenBank-Zugangsnummer: BC137090
• Gene symbol: MACC1
• Gene ID (NCBI): 346389
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS with 0.02% sodium azide and 50% glycerol
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

MACC1, Metalloantigenolytic Cleavage Cartilage Proteinase 1, belongs to the ADAM (a disintegrin and metalloprotease) family. MACC1 was first identified in colon cancer. It is a key prognostic biomarker and is involved in recurrence, metastasis, and survival in solid cancers (PMID: 23815185). MACC1 expression is primarily observed in cartilage, but it's also present in other tissues like bone, synovium, and the developing nervous system (PMID: 36979146).

Publikationen

Species	Application	Title
		Mol Carcinog; The role of metastasis-associated in colon cancer 1 (MACC1) in endometrial carcinoma tumorigenesis and progression.; Authors - Shuo Chen
human	IHC	Int J Med Sci; Bioinformatics Analysis Reveals a Novel Prognostic Model for Esophageal Squamous Cell Carcinoma; Authors - Huan Yang