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MACROD1 Rekombinanter Antikörper

MACROD1 Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

241506C1

Kat-Nr. : 84398-3-PBS

Synonyme

EC:3.2.2.-, EC:3.1.1.106, ADP-ribose glycohydrolase MACROD1, 241506C1, [Protein ADP-ribosylglutamate] hydrolase MACROD1

Filter:
  • Western Blot (WB) analysis of various lysates using MACROD1 Recombinant antibody (84398-3-RR)

    WB analysis using 84398-3-RR (same clone as 84398-3-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84398-3-RR (MACROD1 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84398-3-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84398-3-RR

    Affinity and Kinetic Characterization of 84398-3-RR

    Biolayer interferometry (BLl) kinetic assays of 84398-3-RR against Human MACROD1 were performed. The affinity constant is 11.1 nM.

Geprüfte Anwendungen

Produktinformation

84398-3-PBS bindet in WB, Indirect ELISA MACROD1 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen MACROD1 fusion protein Ag34080
Vollständiger Name MACRO domain containing 1
Berechnetes Molekulargewicht 325 aa, 36 kDa
Beobachtetes Molekulargewicht 28 kDa
GenBank-ZugangsnummerBC008316
Gene symbol MACROD1
Gene ID (NCBI) 28992
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

MACRO domain containing 1 (Macrod1) is also named as LRP16. Macrod1 is an ADP-ribosylhydrolase 1 that is highly enriched in mitochondria, participating in the pathogenesis of cardiovascular diseases (PMID: 38459256). MacroD1 was recruited to the sites of DNA damage via recognition of ADP-ribosylation at DNA lesions (PMID: 32683309). MacroD1 is highly expressed in human and mouse skeletal muscle (PMID: 29410655). Macrod1 may play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation (PMID: 17893710, PMID: 17914104). Macrod1 could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells (PMID: 17893710).