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MBD2 Rekombinanter Antikörper

MBD2 Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

250339G9

Kat-Nr. : 86393-3-PBS

Synonyme

Demethylase, DMTase, Methyl-CpG-binding domain protein 2, Methyl-CpG-binding protein MBD2, NY CO 41

Filter:
  • Western Blot (WB) analysis of various lysates using MBD2 Recombinant antibody (86393-3-RR)

    WB analysis using 86393-3-RR (same clone as 86393-3-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 86393-3-RR (MBD2 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86393-3-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

86393-3-PBS bindet in WB, Indirect ELISA MBD2 und zeigt Reaktivität mit human, Maus

Getestete Reaktivität human, Maus
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Peptid
Vollständiger Name methyl-CpG binding domain protein 2
Berechnetes Molekulargewicht 43 kDa
Beobachtetes Molekulargewicht 43-50 kDa
GenBank-ZugangsnummerNM_003927
Gene symbol MBD2
Gene ID (NCBI) 8932
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

MBD2, also named as DMTase, binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. MBD2 binds hemi-methylated DNA as well. It recruits histone deacetylases and DNA methyltransferases. MBD2 acts as transcriptional repressor and plays a role in gene silencing (PMID:9774669). MBD2 belongs to a highly conserved member of the MBD protein family, is considered a reader of DNA methylation and drives the crosstalk between DNA methylation and histone deacetylation (PMID: 40089655). MBD2 drives breast cancer progression through the modulation of epithelial-to-mesenchymal transition (PMID: 38556549).