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MCOLN3 Rekombinanter Antikörper

MCOLN3 Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

250799F8

Kat-Nr. : 86202-1-PBS

Synonyme

Mucolipin 3, Transient receptor potential channel mucolipin 3, TRP ML3, TRPML3

Filter:
  • Western Blot (WB) analysis of various lysates using MCOLN3 Recombinant monoclonal antibody (86202-1-RR)

    WB analysis using 86202-1-RR (same clone as 86202-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 86202-1-RR (MCOLN3 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86202-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 86202-1-RR

    Affinity and Kinetic Characterization of 86202-1-RR

    Biolayer interferometry (BLl) kinetic assays of 86202-1-RR against Human MCOLN3 were performed. The affinity constant is 0.18 nM.

Geprüfte Anwendungen

Produktinformation

86202-1-PBS bindet in WB, Indirect ELISA MCOLN3 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen MCOLN3 fusion protein Ag4962
Vollständiger Name mucolipin 3
Berechnetes Molekulargewicht 64 kDa
Beobachtetes Molekulargewicht80 kDa
GenBank-ZugangsnummerBC060765
Gene symbol MCOLN3
Gene ID (NCBI) 55283
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

MCOLN3 (Mucolipin 3) is a member of the TRPML (Transient Receptor Potential Mucolipin) gene family and encodes a non-selective cation channel protein that is primarily localized on the membranes of endosomes and lysosomes. MCOLN3 promotes endosome acidification, regulates membrane transport and fusion, and is involved in the autophagy process. Additionally, MCOLN3 is involved in the regulation of intracellular calcium (Ca²⁺) and iron (Fe²⁺) ion homeostasis, maintains lysosomal membrane potential, promotes endosome-lysosome fusion and material transport (such as autophagy), and may also be involved in neuronal signaling and immune regulation.